BOTOX (botulinum type A) entered the market as the first FDA-approved neuromodulator in 1989, and in 2002 was approved as BOTOX Cosmetic for the treatment of moderate-to-severe frown lines in adults. Many people consider Botox to be the “gold standard” of neurotoxins since it was the first in this category to be FDA approved over 20 years ago! It’s safe, effective, and has certainly established itself as a pop culture icon and a household name. For most patients, results will take seven to 14 days to kick in and will last three to four months.